مشخصات پژوهش

Acetaminophen (1) is used worldwide for its analgesic and antipyretic properties. It is widely available and present in many prescription and non-prescription medications. It is an attractively alternative drug for children and people who are sensitive to aspirin [1]. Recently, we have dealt with the electrochemical oxidation of acetaminophen and 4-(Piperazin-1-yl)phenols in aqueous solution [2,3]. The oxidation of these compounds is followed by many chemical reactions such as hydrolysis, hydroxylation, and/or dimerization reaction [2, 3]. In this work with the aim of obtaining information about drug-drug interaction (DDI) we studied the electrochemical oxidation of acetaminophen (paracetamol) in the presence of Duloxetine and Fluvoxamine (3a,3b) (Figure 1) by means of cyclic voltammetry and Controlled-potential coulometry. Our results indicate the participation of electrochemically generated p-quinone imine (NAPQI) produced from electrooxidation of acetaminophen in Michael-type addition reaction with 3a,b. This reaction cause to reduce the concentration of NAPQI and decreases the effective concentration of these drugs. We would like to report a simple electrochemical procedure on the drug-drug interaction between acetaminophen and 3a,b and synthesis a new product of electrooxidation of acetaminophen in the presence of Fluvoxamine (3b) via ECECE mechanism under controlled potential conditions at biological pH and carbon electrode.