مشخصات پژوهش

Tetrapyridinoporphyrazines are derivatives of phthalocyanines which have pyridine rings instead of outerbenzene rings [1]. Porphyrazines containing metal ions such as Zn(II), Ni(II), Cu(II) are strongly stabile. This situation is very important for the application this macrocyclic complexes as a stable catalyst in organic reactions. Pyrazole derivetives are the significant kind of heterocyclic compounds that feature in several pharmaceutical targets and natural products of medicinal interest. Dihydropyrano[2,3-c]pyrazole derivatives have showed a wide variety of biological activities counting anticancer, antimicrobial, anti-inflammatory, insecticidal, and molluscicidal activities. In continuation of our efforts to synthesize of novel catalysts [2] and multicomponent reactions we wish to report the synthesis of vanadium-oxo tetrapyridinoporphyrazine [VO(TPPA)] as an efficient catalyst for the synthesis of dihydropyrano[ 2,3-c]pyrazole through the condensation reaction of aryl aldehydes, ethyl acetoacetate, malononitrile, and phenyl hydrazine under solvent free condition at 60 °C (Fig. 1).