مشخصات پژوهش

One of the main challenges in medicinal chemistry is the design and synthesis of biologically active molecules. Dihydropyrano[2,3-c]pyrazoles play an essential role as biologically active compounds and represent an interesting template for medicinal chemistry. Many of these compounds are known for their antimicrobial, insecticidal and anti-inflammatory activities. Furthermore, dihydropyrano[2,3-c] pyrazoles show molluscicidal activity, and are identified as a screening kit for Chk1 kinase inhibitor. They also find applications as pharmaceutical ingredients and biodegradable agrochemicals [1, 2]. Recently, a very cheap, naturally available (from cell wall of brownalgae), nontoxic, biodegradable and recyclable alginic acidhas been found as an efficient heterogeneous biopolymericBrønsted acid catalyst for organic transformation [3]. In continuation of our interest in the application of heterogeneous catalyst in organic transformation, we report the simple and efficient procedure for one pot synthesis of pyrano[2,3-c]pyrazole derivatives using aryl aldehydes, ethyl acetoacetate, malononitrile, and phenyl hydrazinein presence ofalginic acid as catalyst under solvent free at 60° C condition (Fig. 1).