مشخصات پژوهش

The electrochemical behavior of oxidation of mesalazine drug in the presence of barbituric acid derivatives was investigated by means of cyclic voltammetry and coulometry methods. Investigation was performed in two acidic (pH 1.7) and neutral (pH 7.0) media. It was found that the mentioned reaction shows two clearly different electrochemical behaviors in acidic and neutral media. It was demonstrated that the preferred electrochemical mechanism in acidic medium is a catalytic (EC′) mechanism whereas in neutral medium it is an EC electrochemical mechanism. In kinetics evaluation step, cyclic voltammetry digital simulation method is used for examination and comparison of chemical rate constants.