مشخصات پژوهش

صفحه نخست /Electrochemical Oxidation of ...
عنوان
Electrochemical Oxidation of Acetaminophen in the Presence of Barbituric Acid Derivatives
نوع پژوهش مقاله چاپ‌شده
کلیدواژه‌ها
Acetaminophen
چکیده
Electrochemical oxidation of acetaminophen (1) in the presence of barbituric acid (2a), 1,3-dimethyl barbituric acid (2b), 2- thiobarbituric acid (2c) and 1,3-diethyl-2-thiobarbituric acid (2d) as nucleophiles in aqueous solution has been studied using cyclic voltammetry and controlled-potential coulometry. The results indicate that the p-quinone imine derived from electrooxidation of acetaminophen (1) participates in a Michael addition reaction with 2a-d to form the corresponding barbituric acid derivatives (7a-d). In addition, the homogeneous rate constants were estimated by comparing the experimental cyclic voltammetric responses with the digital simulated results. The electrochemical synthesis of 7a-d has been successfully performed in an undivided cell in good yields and purity at biological pH.
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